The cauda equina is a group of nerve fibers that begin at the lower end of the spinal cord, below the level of the first lumbar vertebrae. The term "cauda equina" means "horse''s tail" in Latin, and this
The crystal structure of a complex between the tail fibre and tail fibre assembly (Tfa) protein of Escherichia coli phage Mu reveals the mechanisms by which Tfa regulates fibre assembly
At the first step of phage infection, the receptor-binding proteins (RBPs) such as tail fibers are responsible for recognizing specific host surface receptors. The proper
In this study, we have determined the structure of the alternative tail fiber subunit, gp52, and compared it with other tail fibers. The results revealed that Mu phage employs different structural
1. Idea A fibre bundle or fiber bundle is a bundle in which every fibre is isomorphic, in some coherent way, to a standard fibre or typical fiber. Usually one also requires that it be locally
Additionally, we conducted a structural classification of 67 fibers and their domains, which identified 16 well-defined tail fiber classes and 89 domains. Our findings suggest the existence of
Here, we propose a pipeline, RBPseg, that defines major domains and segmentation hotspots based on tail fiber primary structure using ESMFold and a
Since a bundle in topology is a union of fibers parametrized by its base space and glued together by the topology of its total space, it provides a basic underlying structure for both the fiber
In this paper, we introduce RBPseg, a method that combines monomeric ESMfold predictions with a novel sigmoid distance pair (sDp) protein
Here, we present the structure of DT57C determined by cryo-EM, and an atomic model of the virus, which was further explored using all-atom molecular dynamics simulations.
Formation of both the tail fiber and the baseplate of bacteriophage T4 depends on the product of T4 gene 57. A single amber mutation in that gene causes loss of two T4-specific proteins. Their
The ST-type pigtail is usually used for wiring equipment, such as fiber distribution frames, fiber modules, etc. The bundled pigtail has only one end with
In this study, we have determined the structure of the alternative tail fiber subunit, gp52, and compared it with other tail fibers. The results revealed that Mu phage
Tail fibers are specialized protein appendages on bacteriophages that recognize and attach to specific bacterial host cell receptors, initiating viral infection.
The tail structure is overall similar to many Mu-like viruses 15, with its use of two tail fibers having implications for host range and recognition 16.
We show that after capsids complete DNA packaging at the surface of the phage nucleus, tails assemble and attach to capsids, and these particles accumulate
Here, we present a high-resolution structure of the tail complex of bacteriophage lambda determined by cryoelectron microscopy. Most component proteins of the lambda tail were
The assembly pathway of the capsid and of the long tail are independent: DNA-full capsids and assembled tails connect to form the complete virion, which is liberated with cell lysis.
We address this challenge by investigating how the tails'' stoichiometry and unique sequence features govern brush structure. We find that sequence charge
Additionally, we conducted a structural classification of 67 fibers and their domains, which identified 16 well-defined tail fiber classes and 89 domains.
However, the field still lacks a sequence-to-structure paradigm linking NF tail amino acid sequence features to the structure and organization of the NF tail layer. Efforts to define sequence
Similar to fiber optic jumpers, tail fibers are classified into single-mode and multimode types, differing in color, wavelength, and transmission distances. Generally, multimode tail fibers are
As the host receptors continuously evolve, the genes present in the tail fibers, tailspikes or tail appendages are selectively pressured to adapt to the ever-changing target, which can range from
RBPseg enables accurate modeling of tail fiber structure, providing the first comprehensive tail fiber structure atlas.
The six bacteriophage T7 tail fibers, homo-trimers of gene product 17, are thought to be responsible for the first specific, albeit reversible, attachment to Escherichia coli lipopolysaccharide.
Intermediates in bacteriophage T4 tail fiber assembly, which accumulate in cells infected with mutants blocked at various stages of tail fiber formation, have been fractionated by velocity sedimentation and
Bacteriophage lambda has a double-stranded DNA genome and a long, flexible, non-contractile tail encoded by a contiguous block of 11 genes downstream of the head genes. The tail
This method segments the tail fiber sequences into smaller fractions, preserving domain boundaries. These segments are then predicted in parallel
Fiber Bundles ''short exact sequence of spaces'' A X X/A gives rise to a long exact se-quence of homology groups, but not to a long exact sequence of homotopy groups due to the failure of
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